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According to the American Cancer Society (ACS), it can have a Chemotherapy injections may cause typical injection site reaction symptoms, including: skin discoloration swelling itching tenderness warmth However, chemotherapy drugs sometimes cause a symptom known as extravasation, which is when the medication leaks from the vein and into the surrounding tissue

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P., et al., Nicotinamide Adenine Dinucleotide Phosphate OxidaseMediated Redox Signaling and Vascular Remodeling by 16Hydroxyestrone in Human Pulmonary Artery Cells: Implications in Pulmonary Arterial Hypertension, Hypertension 68, no